Christos Samakovlis

Christos Samakovlis is professor of Developmental Biology at Stockholm University and SciLifeLab

His laboratory uses high resolution, single cell analysis to understand cellular and molecular mechanisms leading to respiratory organ development.


Key publications:

Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Aliee H, Allon SJ, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Bécavin C, Benhar I, Bergenstråhle J, Bergenstråhle L, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon TM, Cuoco MS, Cuomo ASE, Deprez M, Duclos G, Fine D, Fischer DS, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Habermann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Litviňuková M, Ludwig LS, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr CH, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Strunz M, Sullivan TB, Sun D, Talavera-López C, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK, Deutsch GH, Dutra J, Gaulton KJ, Holden-Wiltse J, Huyck HL, Mariani TJ, Misra RS, Poole C, Preissl S, Pryhuber GS, Rogers L, Sun X, Wang A, Whitsett JA, Xu Y, Alladina J, Banovich NE, Barbry P, Beane JE, Bhattacharyya RP, Black KE, Brazma A, Campbell JD, Cho JL, Collin J, Conrad C, de Jong K, Desai T, Ding DZ, Eickelberg O, Eils R, Ellinor PT, Faiz A, Falk CS, Farzan M, Gellman A, Getz G, Glass IA, Greka A, Haniffa M, Hariri LP, Hennon MW, Horvath P, Hübner N, Hung DT, Huyck HL, Janssen WJ, Juric D, Kaminski N, Koenigshoff M, Koppelman GH, Krasnow MA, Kropski JA, Kuhnemund M, Lafyatis R, Lako M, Lander ES, Lee H, Lenburg ME, Marquette CH, Metzger RJ, Linnarsson S, Liu G, Lo YMD, Lundeberg J, Marioni JC, Mazzilli SA, Medoff BD, Meyer KB, Miao Z, Misharin AV, Nawijn MC, Nikolić MZ, Noseda M, Ordovas-Montanes J, Oudit GY, Pe’er D, Powell JE, Quake SR, Rajagopal J, Tata PR, Rawlins EL, Regev A, Reid ME, Reyfman PA, Rieger-Christ KM, Rojas M, Rozenblatt-Rosen O, Saeb-Parsy K, Samakovlis C, Sanes JR, Schiller HB, Schultze JL, Schwarz RF, Segre AV, Seibold MA, Seidman CE, Seidman JG, Shalek AK, Shepherd DP, Sinha R, Spence JR, Spira A, Sun X, Sundström E, Teichmann SA, Theis FJ, Tsankov AM, Vallier L, van den Berge M, Van Zyl TA, Villani AC, Weins A, Xavier RJ, Yildirim AÖ, Zaragosi LE, Zerti D, Zhang H, Zhang K, Zhang X. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. (2021) Nature medicine

Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P, Banovich NE, Desai T, Eickelberg O, Haniffa M, Horvath P, Kropski JA, Lafyatis R, Lundeberg J, Meyer K, Nawijn MC, Nikolic M, Ordovas Montanes J, Pe’er D, Tata PR, Rawlins E, Regev A, Reyfman P, Samakovlis C, Schultze J, Shalek A, Shepherd D, Spence J, Teichmann S, Theis F, Tsankov A, van den Berge M, von Papen M, Whitsett J, Zaragosi LE, Angelov A, Bals R, Bartholomäus A, Becker A, Bezdan D, Bonifacio E, Bork P, Clavel T, Colme-Tatche M, Diefenbach A, Dilthey A, Fischer N, Förstner K, Frick JS, Gagneur J, Goesmann A, Hain T, Hummel M, Janssen S, Kalinowski J, Kallies R, Kehr B, Keller A, Kim-Hellmuth S, Klein C, Kohlbacher O, Korbel JO, Kurth I, Landthaler M, Li Y, Ludwig K, Makarewicz O, Marz M, McHardy A, Mertes C, Nöthen M, Nürnberg P, Ohler U, Ossowski S, Overmann J, Peter S, Pfeffer K, Poetsch AR, Pühler A, Rajewsky N, Ralser M, Rieß O, Ripke S, Nunes da Rocha U, Rosenstiel P, Saliba AE, Sander LE, Sawitzki B, Schiffer P, Schulte EC, Schultze JL, Sczyrba A, Stegle O, Stoye J, Theis F, Vehreschild J, Vogel J, von Kleist M, Walker A, Walter J, Wieczorek D, Ziebuhr J. Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19. (2020) Immunity

Tucker NR, Chaffin M, Bedi KC, Papangeli I, Akkad AD, Arduini A, Hayat S, Eraslan G, Muus C, Bhattacharyya RP, Stegmann CM, Margulies KB, Ellinor PT, Banovich NE, Barbry P, Black KE, Brazma A, Collin J, Conrad C, Desai T, Duong TE, Eickelberg O, Eils R, Faiz A, Falk C, Farzan M, Glass I, Haniffa M, Horvath P, Hubner N, Hung D, Kaminski N, Koppelman G, Krasnow M, Kropski JA, Kuhnemund M, Lafyatis R, Lako M, Lee H, Leroy S, Linnarson S, Lundeberg J, Medoff B, Meyer K, Miao C, Misharin A, Nawijn M, Nikolic M, Noseda M, Montanes JO, Oudit G, Pe’er D, Powell J, Quake S, Rajagopal J, Rao Tata P, Rawlins E, Regev A, Reyfman P, Rojas M, Rosenblatt-Rosen O, Saeb-Parsy K, Samakovlis C, Schiller H, Schultze J, Schwarz R, Segre A, Seibold M, Seidman J, Seidman C, Shalek A, Shepherd D, Spence J, Spira A, Sun X, Sundström E, Teichmann S, Theis F, Tsankov A, Vallier L, van den Berge M, Whitsett J, Xavier R, Xu Y, Zaragosi LE, Zerti D, Zhang K, Zhang H. Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis (2020) Circulation

Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J, Banovich N, Barbry P, Brazma A, Desai T, Duong TE, Eickelberg O, Falk C, Farzan M, Glass I, Haniffa M, Horvath P, Hung D, Kaminski N, Krasnow M, Kropski JA, Kuhnemund M, Lafyatis R, Lee H, Leroy S, Linnarson S, Lundeberg J, Meyer K, Misharin A, Nawijn M, Nikolic MZ, Ordovas-Montanes J, Pe’er D, Powell J, Quake S, Rajagopal J, Tata PR, Rawlins EL, Regev A, Reyfman PA, Rojas M, Rosen O, Saeb-Parsy K, Samakovlis C, Schiller H, Schultze JL, Seibold MA, Shalek AK, Shepherd D, Spence J, Spira A, Sun X, Teichmann S, Theis F, Tsankov A, van den Berge M, von Papen M, Whitsett J, Xavier R, Xu Y, Zaragosi LE, Zhang K. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. (2020) Cell

Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL, Banovich NE, Barbry P, Brazma A, Collin J, Desai TJ, Duong TE, Eickelberg O, Falk C, Farzan M, Glass I, Gupta RK, Haniffa M, Horvath P, Hubner N, Hung D, Kaminski N, Krasnow M, Kropski JA, Kuhnemund M, Lako M, Lee H, Leroy S, Linnarson S, Lundeberg J, Meyer KB, Miao Z, Misharin AV, Nawijn MC, Nikolic MZ, Noseda M, Ordovas-Montanes J, Oudit GY, Pe’er D, Powell J, Quake S, Rajagopal J, Tata PR, Rawlins EL, Regev A, Reyfman PA, Rozenblatt-Rosen O, Saeb-Parsy K, Samakovlis C, Schiller HB, Schultze JL, Seibold MA, Seidman CE, Seidman JG, Shalek AK, Shepherd D, Spence J, Spira A, Sun X, Teichmann SA, Theis FJ, Tsankov AM, Vallier L, van den Berge M, Whitsett J, Xavier R, Xu Y, Zaragosi LE, Zerti D, Zhang H, Zhang K, Rojas M, Figueiredo F. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. (2020) Nature medicine

Tsarouhas V, Liu D, Tsikala G, Fedoseienko A, Zinn K, Matsuda R, Billadeau DD, Samakovlis C. WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis. (2019) Nature communications

Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. (2019) Nature communications

Hosono C, Matsuda R, Adryan B, Samakovlis C. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. (2015) Nature cell biology

Tiklová K, Senti KA, Wang S, Gräslund A, Samakovlis C. Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila. (2010) Nature cell biology