A study on human heart development:
“A spatiotemporal organ-wide gene expression and cell atlas of the developing human heart”
A spatiotemporal organ-wide gene expression and cell atlas of the developing human heart
Asp M†*, Giacomello S†, Larsson L, Wu C, Fürth D, Qian X, Wärdell E, Custodio J, Reimegård J, Salmén F, Österholm C, Ståhl PL, Sundström E, Åkesson E, Bergmann O, Bienko M, Månsson-Broberg A, Nilsson M, Sylvén C, Lundeberg J*
Cell (2019)
† Authors contributed equally
* Corresponding author
Highlights:
- Profiled spatiotemporal gene expression patterns in human cardiogenesis.
- Mapped cell-type distribution and spatial organization in the human embryonic heart.
- Thoroughly analyzed roles of diverse cell types in cardiac development.
- A publicly available web resource of the human embryonic heart.
Resources:
Single-cell RNA-seq and Spatial Transcriptimics explorer:
https://spatialtranscriptomics3d.shinyapps.io/Developmental_heart_explorer/
In situ sequencing cell mapping visualization:
https://moldia.github.io/heart/
3D Viewer:
http://histo.io/c18heart/